MAPK에 대한 초기 연구는 동물세포가 growth factor를 인식하여 signal을 세포 안으로 전달하여 mitogen을 activation 시키는 mechanism을 밝히는 과정에서 시작되었다.
세포막 안으로 Growth facrot의 signal이 전달되면, Grb2가 Sos에 bindin화고, 이는 Ras-GDP를 Ras-GTP로 바꿔준다. 이는 Raf라는 MAPKKK(MAP kinanse kinase kinase)를 phosph
코카인
코카인의 효과는 암페타민과 비슷하지만 좀 더 짧다. 코카인이 코로 흡입된(snorted) 후 쾌감과 행복감을 느끼고 5분 후 freeze라고 불리는 무감각 상태(numbing sensation)가 된다. 암페타민과 마찬가지로 기운이 넘치고 정신이 뚜렷해 지는 것을 느끼는데, 20-30분 간 지속되며 그 후에 comedown 또는 letdown
tolerate her moods.
You call that moods. I call it rudeness.
But Marcel tolerates her...
Daddy is admirable, and tolerance is a rare virtue.
Very true. And hes always in a good mood.
Even now business is not going so well. -Oh, really?
You know more about his worries than me.
I stay out of it, and I like to keep it that way.
I have my problems and he has his.
A while ago I asked some advice about
freezing cold!.
Close the window. Hai! (yes).
Chiyo, Chiyo, come quickly.
Hatsumomo is at the bath-house
-Here tidy up.
-But she told me to stay ... !
Hatsumomo does not run this okea.
Look whos in my room...
Did you touch this?
I can just hear the General now why
Hatsumomo, you used to smell of jasmine,
What this new perfume? Blowfish?
I told you to never to touch my
things. Can you understand w
freezing winter morning. The boys
are being awakened by a monk, loudly ringing a bell.
Candles are lit.
Napoleon, age 9, sun-tanned, leaps out of bed, rubbing his
arms and shivering. He tries to pour a pitcher of water,
discovering that it has frozen solid.
NAPOLEON
Who has been putting glass in my
pitcher? Look here, someone has
filled my pitcher with glass!
DUFOUR
Oh, my goodness! Someone has f
freezes at
the end of the move.
ANGLE ON
Crowd, who applaud as Cheeba unfolds a brown shopping bag
and holds it out in front of them.
CHEEBA (CONTD)
Thank you very much but please
dont go without giving us some
cheddar, cheese, money. We prefer
twos than fews.
People are digging into their pockets.
CHEEBA (CONTD)
I would like to add that both of us
are homeless. Not that it means
anything.
A WOMA
Freeze! I a holdup!
- Yeah, i a holdup!
Give me the pizza, the cash and some
of them bread sticks, pepperoni-head.
Where you going?
You better slow down!
Hes getting away!
Give me one of them pizzas!
Im falling!
Slow down!
Where you going, pepperoni boy?
You can hide but you cant run!
No... You can run but...
Im gonna kill you!
Tink?
- Tink?
- What?
- Dont tell nobody about this.
- I wont.
Nobody
freezing my ass off.
But were gonna do a good show for you anyway.
For some strange reason...
I failed to realize the first leg of the tour was during Japans rainy season.
So, for three straight weeks we performed the show in a blizzard.
But the dancers are so excited to be performing for an audience...
the world could blow up and they wouldnt care.
I, on the other hand, was not in the mood for E
TOLERANCE FOR
THE ETHNIC RACES
IN DENTON
SHOT OF "D-E" letters. CUT. MOM appears in "D" at sewing
machine. DAD appears clipping hedge in "E."
DAD
YOULL FIND A RAMBLING ROSE
AND A PICKET FENCE
MOM
TENDERNESS AND INNOCENCE
IN DENTON`
SHOT OF "N" and "T" with Officer Parker in "N."
PARKER
YOULL FIND CONFERENCE ROOMS
AND A CHILDRENS PLAYGROUND
DENTON IS A REAL OKAY TOWN
CIVIC PRIDE AND CIVIC DUTY
AND
Freeze!
lts okay. lm on the job.
We got you, sir.
Youre going to be all right, sir.
Why did you drive onto that bridge and start World War lll?
-l saved his life, Frank. -You were lucky, Orin.
Extremely lucky.
The Secret Service gave a direct order not to storm that bridge!
They were responsible for him. Not you!
-What if it went the other way? -l didnt vote for him.
This is funny to you?
-Whats